The
aim of this project is to develop and apply computer-aided methods to model, simulate and predict how biomolecules interact. The focus is on the interactions of proteins. The methods make use of three-dimensional macromolecular structures and combine approaches based on physicochemical principles with those of chemo- and bio-informatics - see our database and software websites.
Applications are made to systems of biological or medicinal interest, and include modeling of:
Signal Recognition Particle (SRP) interactions (with Irmi Sinning, University of Heidelberg)
Cysteine Synthase Complexes (with Ruediger Hell and Markus Wirtz, University of Heidelberg)
