Manuel Glaser

Research Interests

Investigation and prediction of protein-peptide and protein-protein interactions by means of different molecular modeling, simulation, and optimization techniques

Simulation/prediction of peptide behavior in different environments

Computational molecular design of peptide-based drugs

Employment

2019 – present: Research associate, Molecular and Cellular Modeling Group, Heidelberg Institute for Theoretical Studies (Klaus Tschira Foundation-funded subproject 2 of the Informatics4Life initiative: “Structure-based Design of Peptide-based Pharmaceuticals against Striated Muscle Disorders”)

2011 – 2018: Wissenschaftlicher Mitarbeiter, Theoretical Chemical Biology and Protein Modelling Group, Technical University of Munich (mainly: application and evaluation of biomolecular modeling & simulation/structural bioinformatics techniques to investigate and predict protein-(non)ribosomal peptide binding in the context of CRC749 & CRC1035 and in the context of translational immunotherapy/virology in collaboration with groups at the TUM School of Medicine)

Education

2011 – present: Doctoral candidate, Theoretical Chemical Biology and Protein Modelling Group, Technical University of Munich (doctoral dissertation in preparation)

2011 – M.Sc. in Biology (specialization: Molecular Biology), Technical University of Munich

2008 – B.Sc. in Biology, Technical University of Munich

Publications

Glaser M, Bruce NJ, Han SB, Wade RC. Simulation of the Positive Inotropic Peptide S100A1ct in Aqueous Environment by Gaussian Accelerated Molecular Dynamics. J Phys Chem B. 2021 May 4;125(18):4654-4666.

Audehm S, Glaser M*, Pecoraro M*, Bräunlein E*, Mall S, Klar R, Effenberger M, Albers J, Bianchi HO, Peper J, Yusufi N, Busch DH, Stevanović S, Mann M, Antes I, Krackhardt AM. Key features relevant to select antigens and TCR from the MHC-mismatched repertoire to treat cancer. Front Immunol. 2019 Jun 28 (*: authors contributed equally to this work)

Ugur I, Schroft M, Marion A, Glaser M, Antes I. Predicting the bioactive conformations of macrocycles: A molecular dynamics-based docking procedure with DynaDock. J Mol Model. 2019 Jun 20;25(7):197.

Ugur I, Schatte M, Marion A, Glaser M, Boenitz-Dulat M, Antes I. Ca2+ binding induced sequential allosteric activation of sortase A: An example for ion-triggered conformational selection. PLOS One. 2018 Oct 15;13(10).

Karimzadeh H, Kiraithe MM, Kosinska AD, Glaser M, Fiedler M, Oberhardt V, Alizei ES, Hofmann M, Mok JY, Nguyen M, van Esch WJE, Budeus B, Grabowski J, Homs M, Olivero A, Keyvani H, Rodriguez-Frias F, Tabernero D, Buti M, Heinold A, Alavian SM, Bauer T, Wiesch JSZ, Raziorrouh B, Hoffmann D, Smedile A, Rizzetto M, Wedemeyer H, Timm J, Antes I, Neumann-Haefelin C, Protzer U, Roggendorf M. Amino Acid Substitutions within HLA-B*27-Restricted T Cell Epitopes Prevent Recognition by Hepatitis Delta Virus-Specific CD8(+) T Cells. J Virol. 2018 Jun 13;92(13):e01891-17.

Marion A, Groll M, Scharf DH, Scherlach K, Glaser M, Sievers H, Schuster M, Hertweck C, Brakhage AA, Antes I, Huber EM. Gliotoxin Biosynthesis: Structure, Mechanism, and Metal Promiscuity of Carboxypeptidase GliJ. ACS Chem Biol. 2017 Jul 21;12(7):1874-1882.

Schneider M*, Rosam M*, Glaser M, Patronov A, Shah H, Back KC, Daake MA, Buchner J, Antes I. BiPPred: Combined sequence- and structure-based prediction of peptide binding to the Hsp70 chaperone BiP. Proteins. 2016 Oct;84(10):1390-407. (*: authors contributed equally to this work)

Duell ER*, Glaser M*, Le Chapelain C, Antes I, Groll M, Huber EM. Sequential Inactivation of Gliotoxin by the S-Methyltransferase TmtA. ACS Chem Biol. 2016 Apr 15;11(4):1082-9. (*: authors contributed equally to this work)

Hackl MW*, Lakemeyer M*, Dahmen M, Glaser M, Pahl A, Lorenz-Baath K, Menzel T, Sievers S, Böttcher T, Antes I, Waldmann H, Sieber SA. Phenyl Esters Are Potent Inhibitors of Caseinolytic Protease P and Reveal a Stereogenic Switch for Deoligomerization. J Am Chem Soc. 2015 Jul 8;137(26):8475-83. (*: authors contributed equally to this work)