Welcome Csaba!

A warm welcome to Csaba Daday that joined us from the Biomolecular Electronic Structure group of Prof. Claudia Filippi in Twente. Csaba will investigate the effect of force on the molecular components of epithelial junctions. Welcome!

A warm welcome to Sebastian Sturm!

Sebastian Sturm from the Institute of Theoretical Physics in Leipzig has joined the group to work on the fitting of data obtained from pulling simulations. Sebastian, Prof. Dr. Klaus Kroy and their collaborators are the co-authors of a recent article appeared on Nature Communications aiming to bridge pulling simulations and rapid force spectroscopy experiments through a…

Revealing the behaviour of von Willebrandt Factor through experiments and simulations

Dr. Camilo Aponte-Santamaria has recently published three papers revealing the behaviour of the von Willebrandt factor. The work describes a new force-sensory mechanism for VWF-platelet binding, which addresses the inactivation of VWF by shielding of its adhesion sites, combining molecular dynamics (MD) simulations, atomic force microscopy (AFM), and microfluidic experiments. The simulations demonstrate that the…

The reactivity of click-chemistry isomers revealed by QM calculations!

In this study Wagner et al. systematically quantified the reactivity of newly discovered TCO* conformers with tetrazines in comparison to other common click-reactions using density functional calculations. The calculations were interfaced to experimental kinetic measurements used for comparison. Furthermore, a new type of click-reaction, termed SPINEDAC (Strain Promoted Inherently Normal Electron Demand Diels-Alder Cycloaddition), was…

Rescuing Proteins from Collapse

One of the cornerstones of structural biology envisions that the structure of a molecule is tightly related to its function. The recent discovery of intrinsically disordered proteins (IDPs) appeared to invalidate such a concept, as IDPs do not show any clear structure but are still able to perform complex functions inside cells. Nevertheless, IDPs tend…

Research that gets under the skin: HITS involved in new DFG Program

A new Priority Program of the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) focuses on our biggest organ – the skin. The program is titled “Epithelial intercellular junctions” and aims at examining these junctions. Prof. Thomas Magin from the Translational Centre for Regenerative Medicine (TRM) and Biology department of Leipzig University coordinates the program. Epithelial cells…

Shenc symposium on von Willebrand factor

We are happy to announce the upcoming of a symposium on the most recent advances in von Willebrand factor research. The symposium will be held within the Shenc consortium and will cover a broad range of aspects of von Willebrand function and disfunction, its role in homeostasis and diseases, as well as the biomechanical aspects…