The need for speed: Why malaria parasites are faster than human immune cells

Elementary cytoskeleton protein is different in parasites and represents a starting point for a possible new therapy against malaria infections. Researchers from the Heidelberg University Hospital, the Centre for Molecular Biology at the University of Heidelberg (ZMBH), and the Heidelberg Institute for Theoretical Studies (HITS) have published these findings in the journal “PLOS Biology”.

Accelerated reactions in condensed bio-matter?

HITS researcher Dr. Kashif Sadiq explores ribonucleoprotein granules, a condensed form of bio-matter found inside cells. He investigates whether the rate of enzymatic reactions in these membrane-less granules is accelerated. If true, this would lead to new insights in how cells regulate their biochemistry and may shed light on the origins of life on Earth. The project is funded by the Volkswagen Stiftung with an “Experiment!” grant.

A matter of mobility: multidisciplinary paper suggests new strategy for drug discovery

A joint industry/academia study of a cancer target protein reveals unusual relation between binding site flexibility and drug-target lifetime. The results, published in “Nature Communications”, suggest a new strategy for drug discovery. The research was done in the framework of the Kinetics for Drug Discovery K4DD consortium, supported by the Innovative Medicines Initiative.

Announcing Fourth Biological Diffusion and Brownian Dynamics Brainstorm Meeting (BDBDB 4)

Biological Diffusion and Brownian Dynamics Brainstorm 4 (BDBDB4) will, like the previous meetings (the last was BDBDB3), provide a forum for intensive discussions about the current state of experimental and theoretical studies of biological diffusion, with a focus on the Brownian Dynamics method for simulating biological macromolecules. The first BDBDB meeting was held in 2007…

New TRAPP webserver for studying TRAnsient Pockets in Proteins

Many drugs exert their therapeutic effects by binding in cavities or pockets on specific target protein macromolecules. The binding pockets on proteins are mobile and dynamic and constantly changing shape. Some pockets or subpockets can be described as transient because they are not always present in the given protein. In structure-based drug design procedures, the…

Young Researcher´s award goes to HITS doctoral student

Mehmet Ali Öztürk, PhD student at HITS and at the Hartmut Hoffmann-Berling International Graduate School of Molecular and Cellular Biology (HBIGS) of Heidelberg University, has been awarded the „Preis der Dr. Alexander und Dr. Rosemarie Bauer-Stiftung“ of Heidelberg University.  The 3000 Euro award enables young researchers to have a research stay in Germany or abroad.…

On the front cover: Multiexpert Platform for the Identification of Hits Targeting Parasitic Enzymes

In the New Medicines for Trypanosomatidic Infections (NMTRypI) project funded by the EU and completed in January 2017, in which 13 partners participated, including the HITS Molecular and Cellular Modeling (MCM) and Scientific Databases and Visualization (SDBV) groups, novel anti-leishmanial and anti-trypanosomal hit compounds that inhibit pteridine reductase 1 (PTR1) were discovered. PTR1 is an enzyme of…