{"id":1412,"date":"2014-10-21T18:31:44","date_gmt":"2014-10-21T16:31:44","guid":{"rendered":"http:\/\/www.h-its.org\/?page_id=1412"},"modified":"2026-05-26T15:30:01","modified_gmt":"2026-05-26T13:30:01","slug":"projects","status":"publish","type":"page","link":"https:\/\/www.h-its.org\/de\/forschung\/mcm\/projects\/","title":{"rendered":"Projekte"},"content":{"rendered":"\n

Unser Hauptziel ist die Entwicklung und Anwendung computergest\u00fctzter Methoden zur Modellierung, Simulation und Vorhersage der Interaktion von Biomolek\u00fclen, wobei der Fokus auf der Interaktion von Proteinen liegt. Dazu nutzen wir dreidimensionale makromolekulare Strukturen und kombinieren Ans\u00e4tze, die auf physikochemischen Prinzipien beruhen, mit Chemo- und Bioinformatik. Einige Projekte werden auf dieser Seite n\u00e4her erl\u00e4utert (Die Inhalte sind nur auf Englisch verf\u00fcgbar).<\/p>\n\n\n\n

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SIMPLAIX Project 8: Machine-Learning Aided Multiscale Modeling of Interprotein Electron Transfer and Enzyme Mechanism<\/p>\n

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2.06.2026<\/div>\n <\/div>\n

Cytochrome P450 enzymes (CYPs) are membrane-bound monooxygenases that play central roles in drug metabolism and steroid biosynthesis. They are able to …<\/p>\n Mehr erfahren<\/a>\n <\/div>\n<\/div>\n \n

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SynthImmune: Design of peptide-based immunogens for tackling malaria<\/p>\n

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2.06.2026<\/div>\n <\/div>\n

The human immune system is powerful, yet it can be evaded by certain types of cancer and infection, leading to severe …<\/p>\n Mehr erfahren<\/a>\n <\/div>\n<\/div>\n \n

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CompIF: Effiziente Berechnung der intermolekularen Kr\u00e4fte f\u00fcr biomolekulare Simulationen<\/p>\n

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31.10.2023<\/div>\n <\/div>\n

Die Struktur, Dynamik und Wechselwirkungen von Biomolek\u00fclen k\u00f6nnen mit Molek\u00fclsimulationen im Detail erforscht werden. Durch wiederholtes L\u00f6sen …<\/p>\n Mehr erfahren<\/a>\n <\/div>\n<\/div>\n \n

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Structure-based drug discovery<\/p>\n

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14.01.2015<\/div>\n <\/div>\n

Proteins are dynamic and constantly changing their shape. This flexibility not only presents a challenge to to structure-based drug design approaches …<\/p>\n Mehr erfahren<\/a>\n <\/div>\n<\/div>\n \n

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Macromolecular interactions and diffusional association<\/p>\n

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14.01.2015<\/div>\n <\/div>\n

We are developing methods to predict protein-protein interactions and how proteins bind to surfaces. These methods rely on Brownian dynamics simulation …<\/p>\n Mehr erfahren<\/a>\n <\/div>\n<\/div>\n \n

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Protein structures in systems biology<\/p>\n

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14.01.2015<\/div>\n <\/div>\n

We are working on developing approaches to bridge between protein structures and biochemical networks, from the molecular to the cellular level….<\/p>\n Mehr erfahren<\/a>\n <\/div>\n<\/div>\n \n <\/div>\n\n <\/div>\n\n\n\n

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Unser Hauptziel ist die Entwicklung und Anwendung computergest\u00fctzter Methoden zur Modellierung, Simulation und Vorhersage der Interaktion von Biomolek\u00fclen, wobei …<\/p>\n","protected":false},"author":3,"featured_media":40653,"parent":42,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"page-templates\/group.php","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"hits-research-group":[1298],"class_list":["post-1412","page","type-page","status-publish","has-post-thumbnail","hentry","hits-research-group-mcm-de"],"acf":[],"yoast_head":"\nProjekte - HITS gGmbH<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.h-its.org\/de\/forschung\/mcm\/projects\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Projekte - HITS gGmbH\" \/>\n<meta property=\"og:description\" content=\"Unser Hauptziel ist die Entwicklung und Anwendung computergest\u00fctzter Methoden zur Modellierung, Simulation und Vorhersage der Interaktion von Biomolek\u00fclen, wobei ...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.h-its.org\/de\/forschung\/mcm\/projects\/\" \/>\n<meta property=\"og:site_name\" content=\"HITS gGmbH\" \/>\n<meta property=\"article:modified_time\" content=\"2026-05-26T13:30:01+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.h-its.org\/de\/wp-content\/uploads\/sites\/2\/2019\/12\/MCM.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1340\" \/>\n\t<meta property=\"og:image:height\" content=\"1340\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Gesch\u00e4tzte Lesezeit\" \/>\n\t<meta name=\"twitter:data1\" content=\"3\u00a0Minuten\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.h-its.org\\\/de\\\/forschung\\\/mcm\\\/projects\\\/\",\"url\":\"https:\\\/\\\/www.h-its.org\\\/de\\\/forschung\\\/mcm\\\/projects\\\/\",\"name\":\"Projekte - 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