{"id":31750,"date":"2019-03-20T16:56:36","date_gmt":"2019-03-20T15:56:36","guid":{"rendered":"http:\/\/www.h-its.org\/karriere\/computational-biology-cbi-group\/"},"modified":"2025-02-26T13:08:34","modified_gmt":"2025-02-26T12:08:34","slug":"computational-biology-cbi-group","status":"publish","type":"page","link":"https:\/\/www.h-its.org\/de\/forschung\/computational-biology-cbi-group\/","title":{"rendered":"Computational Biology (CBI) Gruppe"},"content":{"rendered":"\n

Im Februar 2013 nahm die neue\nJunior-Forschungsgruppe \u201eComputational Biology\u201c (CBI) unter Leitung von Dr.\nSiegfried Schloissnig ihre Arbeit am HITS auf. Das Augenmerk der CBI-Gruppe lag\nauf seltsamen Lebewesen mit atemberaubenden Eigenschaften: Die Gruppe\nbesch\u00e4ftigte sich mit dem Erbgut von Salamandern und Plattw\u00fcrmern. <\/p>\n\n\n\n

Siegfried Schloissnig und seine Gruppe entwickelten\nam HITS neue Ans\u00e4tze f\u00fcr die sogenannte \u201eDe-novo-Assemblierung\u201c, die\nRekonstruktion von Genomsequenzen mit Hilfe von DNA-Sequenzierger\u00e4ten und\nbioinformatischen Methoden. Beim Sequenzieren nach heute \u00fcblichen Methoden wird\ndie DNA mehrfach kopiert. Die Kopien werden dabei zuf\u00e4llig in viele kleine\nFragmente aufgesplittert. Diese Fragmente werden durch bioinformatische\nMethoden auf \u00dcberlappungen untersucht und dann wieder neu zusammengesetzt. Je\nkleiner die Fragmente und komplexer das Genom, desto schwieriger wird das\nProblem. Noch schwieriger ist es, wenn kein vergleichbares Genom vorliegt und\ndie Forscher das Genom aus Sequenzen \u201ede novo\u201c, das hei\u00dft: neu zusammensetzen\nm\u00fcssen. Wie zum Beispiel bei Plattw\u00fcrmern.<\/p>\n\n\n\n

Nach fast f\u00fcnf Jahren intensiver Forschung gelang es Dr. Siegfried Schloissnig und seinem Team, gemeinsam mit Kollegen aus Dresden und Wien, das Genom des mexikanischen
Salamanders Axolotl<\/a> und des Plattwurms
Schmidtea mediterranea zu entschl\u00fcsseln. Beide Tiere sind wichtige Organismen in der Regenerationsforschung. Die Forschungsergebnisse wurde im Fachjournal \u201eNature\u201c ver\u00f6ffentlicht und erreichten eine hohe Medienresonanz. Schloissnig und seine Mitarbeiter entwickelten daf\u00fcr am HITS seit 2013 eine v\u00f6llig neue Software, den Genom-Assembler \u201eMARVEL.\u201c Das Programm kann ein Genom auch aus extrem gro\u00dfen oder hoch repetitiven Erbgutinformationen rekonstruieren.<\/p>\n\n\n\n

Seit 2018 ist Siegfried Schloissnig am Institut f\u00fcr Molekulare Pathologie
(IMP) in<\/a> Wien f\u00fcr den informatischen Teil der Regenerationsforschung zust\u00e4ndig.<\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

Die CBI Gruppe entwickelte neue Ans\u00e4tze f\u00fcr die sogenannte \u201eDe-novo-Assemblierung\u201c, die Rekonstruktion von Genomsequenzen mit Hilfe von DNA-Sequenzierger\u00e4ten …<\/p>\n","protected":false},"author":107,"featured_media":40669,"parent":4,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-templates\/group.php","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"hits-research-group":[1369],"class_list":["post-31750","page","type-page","status-publish","has-post-thumbnail","hentry","hits-research-group-computational-biology-de"],"acf":[],"yoast_head":"\nComputational Biology (CBI) Gruppe - HITS gGmbH<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.h-its.org\/de\/forschung\/computational-biology-cbi-group\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Computational Biology (CBI) Gruppe - 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