{"id":3818,"date":"2014-11-24T12:00:26","date_gmt":"2014-11-24T11:00:26","guid":{"rendered":"http:\/\/www.h-its.org\/?p=3818"},"modified":"2019-09-24T11:40:29","modified_gmt":"2019-09-24T09:40:29","slug":"conformational-dynamics-of-intrinsically-disordered-proteins","status":"publish","type":"post","link":"https:\/\/www.h-its.org\/de\/2014\/11\/24\/conformational-dynamics-of-intrinsically-disordered-proteins\/","title":{"rendered":"Conformational dynamics of intrinsically disordered proteins"},"content":{"rendered":"\n<p>Intrinsically disordered proteins (IDPs) lack, by definition, of a well-defined three-dimensional structure and therefore explore a much larger conformational ensemble with respect to structured proteins. Nevertheless, as for structured proteins, understanding the conformational dynamics of IDPs is key to comprehend their functional features in solution. Despite of the progresses made to sample the conformational dynamics of IDPs by means of computer&nbsp;simulations, the computationally-derived ensembles still lack a full match with&nbsp;experiments. This projects develops around the idea of understanding the determinants of such mismatches and improving our current ability to sample IDPs dynamics with computer simulations.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Intrinsically disordered proteins (IDPs) lack, by definition, of a well-defined three-dimensional structure and therefore explore a much larger conformational ensemble with &#8230;<\/p>\n","protected":false},"author":82,"featured_media":29366,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[1],"hits-research-group":[1296],"class_list":["post-3818","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-gruppen-news","hits-research-group-mbm-de"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Conformational dynamics of intrinsically disordered proteins - HITS gGmbH<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.h-its.org\/de\/2014\/11\/24\/conformational-dynamics-of-intrinsically-disordered-proteins\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Conformational dynamics of intrinsically disordered proteins - HITS gGmbH\" \/>\n<meta property=\"og:description\" content=\"Intrinsically disordered proteins (IDPs) lack, by definition, of a well-defined three-dimensional structure and therefore explore a much larger conformational ensemble with ...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.h-its.org\/de\/2014\/11\/24\/conformational-dynamics-of-intrinsically-disordered-proteins\/\" \/>\n<meta property=\"og:site_name\" content=\"HITS gGmbH\" \/>\n<meta property=\"article:published_time\" content=\"2014-11-24T11:00:26+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2019-09-24T09:40:29+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.h-its.org\/de\/wp-content\/uploads\/sites\/2\/2014\/11\/IDP.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1536\" \/>\n\t<meta property=\"og:image:height\" content=\"927\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Obarska-Kosinska, Agnieszka\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Verfasst von\" \/>\n\t<meta name=\"twitter:data1\" content=\"Obarska-Kosinska, Agnieszka\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.h-its.org\\\/de\\\/2014\\\/11\\\/24\\\/conformational-dynamics-of-intrinsically-disordered-proteins\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.h-its.org\\\/de\\\/2014\\\/11\\\/24\\\/conformational-dynamics-of-intrinsically-disordered-proteins\\\/\"},\"author\":{\"name\":\"Obarska-Kosinska, Agnieszka\",\"@id\":\"https:\\\/\\\/www.h-its.org\\\/de\\\/#\\\/schema\\\/person\\\/6d589bfb186914c90e945a0851df6afd\"},\"headline\":\"Conformational dynamics of intrinsically disordered proteins\",\"datePublished\":\"2014-11-24T11:00:26+00:00\",\"dateModified\":\"2019-09-24T09:40:29+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.h-its.org\\\/de\\\/2014\\\/11\\\/24\\\/conformational-dynamics-of-intrinsically-disordered-proteins\\\/\"},\"wordCount\":105,\"image\":{\"@id\":\"https:\\\/\\\/www.h-its.org\\\/de\\\/2014\\\/11\\\/24\\\/conformational-dynamics-of-intrinsically-disordered-proteins\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.h-its.org\\\/de\\\/wp-content\\\/uploads\\\/sites\\\/2\\\/2014\\\/11\\\/IDP.png\",\"articleSection\":[\"Gruppen News\"],\"inLanguage\":\"de\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.h-its.org\\\/de\\\/2014\\\/11\\\/24\\\/conformational-dynamics-of-intrinsically-disordered-proteins\\\/\",\"url\":\"https:\\\/\\\/www.h-its.org\\\/de\\\/2014\\\/11\\\/24\\\/conformational-dynamics-of-intrinsically-disordered-proteins\\\/\",\"name\":\"Conformational dynamics of intrinsically disordered proteins - 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