{"id":49699,"date":"2025-02-12T16:43:31","date_gmt":"2025-02-12T15:43:31","guid":{"rendered":"https:\/\/www.h-its.org\/de\/?p=49699"},"modified":"2025-02-12T16:43:32","modified_gmt":"2025-02-12T15:43:32","slug":"designer-peptid-i4l","status":"publish","type":"post","link":"https:\/\/www.h-its.org\/de\/2025\/02\/12\/designer-peptid-i4l\/","title":{"rendered":"Designer-Peptid zur Bek\u00e4mpfung akuter Herzmuskelschw\u00e4che"},"content":{"rendered":"\n

Forschende der Universit\u00e4t Heidelberg, des Universit\u00e4tsklinikums Heidelberg (UKHD) und des Heidelberger Instituts f\u00fcr Theoretische Studien (HITS) haben ein synthetisches Peptid entwickelt, das auf dem nat\u00fcrlichen Protein S100A1 basiert \u2013 einem nahezu universellen \u201eTreibstoff\u201c f\u00fcr geschw\u00e4chte Herzen. Sie kombinierten dazu computergest\u00fctzte Methoden mit Laborstudien, um die therapeutische Wirkung des sogenannten S100A1ct-Peptidmolek\u00fcls zu untersuchen. Die Ergebnisse wurden in der Fachzeitschrift \u201eCirculation\u201c ver\u00f6ffentlicht.<\/strong><\/p>\n\n\n

\n
\"Bild<\/a>
A. Aus der molekularen Struktur des Herzkraftproteins S100A1 entwickelten die Heidelberger Wissenschaftlerinnen und Wissenschaftler mit Hilfe computergest\u00fctzter Modellierung und Tests an Herzmuskelzellen das synthetische Kurzpeptid S100A1ct. Es ahmt die biologischen Wirkungen des nat\u00fcrlichen Proteins nach.
B. In die Blutbahn von Tieren mit gesunden und erkrankten Herzen (Herzmuskelschw\u00e4che) verabreicht, steigert das S100A1ct-Peptid die Pumpkraft bei beiden Gruppen und stabilisiert zudem den Herzrhythmus der geschw\u00e4chten Herzen. Quelle: Universit\u00e4tsklinikum Heidelberg<\/figcaption><\/figure>\n<\/div>\n\n\n

Vom HITS war die Gruppe \u201eMolecular and Cellular Modeling\u201c unter der Leitung von Rebecca Wade an dem Projekt beteiligt. Der Ansatz: Experimente an Herzmuskelzellen und Tieren sowie rechnergest\u00fctzte molekulare Modellierung zu kombinieren. \u201eUnser Labor hat f\u00fcr dieses Projekt eine ma\u00dfgeschneiderte computergest\u00fctzte Modellierungspipeline entwickelt, um die molekulare Struktur des Peptids sowie seine Wechselwirkungen mit anderen molekularen Effektoren in den erkrankten Herzzellen zu modellieren\u201c, so Rebecca Wade. \u201eDaraus ergab sich, wie die folgenden Experimente gestaltet sein mussten, um die molekularen Wirkmechanismen von S100A1ct gezielt zu untersuchen.\u201c<\/p>\n\n\n\n

Den Rahmen f\u00fcr die erfolgreiche Zusammenarbeit bildete die von der Klaus Tschira Stiftung gef\u00f6rderte Initiative \u201eInformatics for Life (I4L<\/a>)\u201c. Weitere finanzielle Unterst\u00fctzung erhielt das Projekt vom Deutschen Zentrum f\u00fcr Herz-Kreislauf-Forschung (DZHK) mit der translationalen Projektf\u00f6rderung des Bundesministeriums f\u00fcr Bildung und Forschung aus dem Programm \u201ePr\u00e4klinische konfirmatorische Studien\u201c.<\/p>\n\n\n\n

Zur ausf\u00fchrlichen Pressemitteilung des Universit\u00e4tsklinikums: https:\/\/www.klinikum.uni-heidelberg.de\/newsroom\/designer-peptid-zur-bekaempfung-akuter-herzmuskelschwaeche\/<\/a><\/p>\n\n\n\n

<\/p>\n\n\n\n

Publikation:
<\/strong>Kehr D, Ritterhoff J, Glaser M, et al. S100A1ct: A Synthetic Peptide Derived From S100A1 Protein Improves Cardiac Performance and Survival in Preclinical Heart Failure Models. Circulation. Published online November 21, 2024. doi:10.1161\/CIRCULATIONAHA.123.066961<\/a><\/em><\/p>\n\n\n\n

Wissenschaftlicher Kontakt:<\/strong><\/p>\n\n\n\n

 Prof. Dr. Patrick Most 
Sektion f\u00fcr Molekulare und Translationale Kardiologie
Klinik f\u00fcr Kardiologie, Angiologie und Pneumologie des UKHD
Medizinische Fakult\u00e4t Heidelberg der Universit\u00e4t Heidelberg
E-Mail: patrick.most@med.uni-heidelberg.de<\/a><\/a>

<\/p>\n\n\n\n

Prof. Dr. Rebecca Wade
Gruppenleiterin Molecular and Cellular Modeling
Heidelberger Institut f\u00fcr Theoretische Studien (HITS)
Zentrum f\u00fcr Molekulare Biologie (ZMBH) der Universit\u00e4t Heidelberg
Medizinische Fakult\u00e4t Heidelberg der Universit\u00e4t Heidelberg
E-Mail: r.wade@zmbh.uni-heidelberg.de<\/a><\/a><\/p>\n\n\n\n

Medienkontakt:<\/strong><\/p>\n\n\n\n

Dr. Stefanie Seltmann
Pressesprecherin
Universit\u00e4tsklinikum Heidelberg
presse@med.uni-heidelberg.de<\/a><\/p>\n\n\n\n

Dr. Peter Saueressig
Head of Communications
Heidelberger Institut f\u00fcr Theoretische Studien (HITS)
comms@h-its.org<\/a>

<\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

Forschende der Universit\u00e4t Heidelberg, des Universit\u00e4tsklinikums Heidelberg (UKHD) und des Heidelberger Instituts f\u00fcr Theoretische Studien (HITS) haben ein …<\/p>\n","protected":false},"author":58,"featured_media":49700,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[1,92],"hits-research-group":[1298],"class_list":["post-49699","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-gruppen-news","category-wissenschaftsnews","hits-research-group-mcm-de"],"acf":[],"yoast_head":"\nDesigner-Peptid zur Bek\u00e4mpfung akuter Herzmuskelschw\u00e4che - HITS gGmbH<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.h-its.org\/de\/2025\/02\/12\/designer-peptid-i4l\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Designer-Peptid zur Bek\u00e4mpfung akuter Herzmuskelschw\u00e4che - 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