{"id":50990,"date":"2026-08-06T09:47:03","date_gmt":"2026-08-06T07:47:03","guid":{"rendered":"https:\/\/www.h-its.org\/de\/event\/hits-simplaix-joint-colloquium-yuji-sugita-how-can-protein-droplets-be-dissolved\/"},"modified":"2026-08-06T10:11:07","modified_gmt":"2026-08-06T08:11:07","slug":"hits-simplaix-joint-colloquium-yuji-sugita","status":"publish","type":"tribe_events","link":"https:\/\/www.h-its.org\/de\/event\/hits-simplaix-joint-colloquium-yuji-sugita\/","title":{"rendered":"HITS-SIMPLAIX Joint Colloquium Yuji Sugita &#8211; How Can Protein Droplets Be Dissolved?"},"content":{"rendered":"<p>&nbsp;<\/p>\n<p>by <a href=\"https:\/\/www.bdr.riken.jp\/en\/research\/labs\/sugita-y\/index.html\">Yuji Sugita<\/a>, RIKEN Center for Biosystems Dynamics Research, Tokio<\/p>\n<p>For a CV, <a href=\"https:\/\/www.h-its.org\/wp-content\/uploads\/2026\/08\/CV.pdf\">click here.<\/a><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>It is well known that bimolecular droplets formed by liquid-liquid phase separation (LLPS) play a crucial role in understanding cellular biological processes and elucidating molecular mechanisms underlying several diseases. Consequently, there has been active research using computational simulations, including molecular dynamics (MD), to understand droplet formation and dynamic properties of intrinsically disordered proteins and RNA within droplets. However, how these droplets dissolve in cells remains unresolved. We are attempting to understand the mechanism by which Hero proteins\u2014highly charged, intrinsically disordered proteins\u2014dissolve specific droplets formed by their client proteins. It is known experimentally that Hero11 targets droplets composed of TDP-43, while Hero9 targets droplets composed of PolyQ. We used multiscale MD simulations to investigate in detail the molecular mechanisms underlying droplet dissolution by these two Hero proteins. The mechanisms we identified through these calculations differ significantly, suggesting the existence of sequence-dependent droplet dissolution mechanisms.<\/p>\n<p>We also discuss multi-scale simulations connecting coarse-grained and atomistic models through a machine learning Backmapping tool, <a href=\"https:\/\/github.com\/genesis-release-r-ccs\/cgback\">CGback<\/a>. This tool is a generative AI model that rebuilds atomistic structures from C\u03b1 coordinates. Using CGback, CG-model structures of protein droplets are easily transformed to atomistic coordinates without chirality errors, steric clashes with other proteins.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><strong>REGISTRATION:<\/strong><\/p>\n<article>The talk will be hybrid.<\/article>\n<article>\n<article>If you would like to participate online, please register in advance <a href=\"https:\/\/kta-email.zoom.us\/meeting\/register\/82epNfoGR9CcwKOd7OM1uQ\">here<\/a>.<\/article>\n<article><\/article>\n<article><\/article>\n<article><\/article>\n<article>After registering, you will receive a confirmation email containing information about joining the meeting.<\/article>\n<article><\/article>\n<article><\/article>\n<article>In case you are not able to attend, you can watch the talk afterwards on the HITS YouTube channel:\u00a0<a href=\"https:\/\/www.youtube.com\/user\/TheHITSters\" target=\"_blank\" rel=\"noopener noreferrer\" data-fancybox-group=\"fb_gallery_0_0\">https:\/\/www.youtube.com\/user\/TheHITSters<\/a>.<\/article>\n<\/article>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; by Yuji Sugita, RIKEN Center for Biosystems Dynamics Research, Tokio For a CV, click here. &nbsp; &nbsp; It is well &#8230;<\/p>\n","protected":false},"author":168,"featured_media":50992,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"_tribe_events_status":"","_tribe_events_status_reason":"","footnotes":""},"tags":[],"hits-research-group":[1319,1422],"tribe_events_cat":[1408,1345],"class_list":["post-50990","tribe_events","type-tribe_events","status-publish","has-post-thumbnail","hentry","hits-research-group-hits","hits-research-group-simplaix","tribe_events_cat-kolloquien","tribe_events_cat-oeffentliche-veranstaltungen","cat_kolloquien","cat_oeffentliche-veranstaltungen"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>HITS-SIMPLAIX Joint Colloquium Yuji Sugita - How Can Protein Droplets Be Dissolved? - HITS gGmbH<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.h-its.org\/de\/event\/hits-simplaix-joint-colloquium-yuji-sugita\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"HITS-SIMPLAIX Joint Colloquium Yuji Sugita - How Can Protein Droplets Be Dissolved? - HITS gGmbH\" \/>\n<meta property=\"og:description\" content=\"&nbsp; by Yuji Sugita, RIKEN Center for Biosystems Dynamics Research, Tokio For a CV, click here. &nbsp; &nbsp; It is well ...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.h-its.org\/de\/event\/hits-simplaix-joint-colloquium-yuji-sugita\/\" \/>\n<meta property=\"og:site_name\" content=\"HITS gGmbH\" \/>\n<meta property=\"article:modified_time\" content=\"2026-08-06T08:11:07+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.h-its.org\/de\/wp-content\/uploads\/sites\/2\/2026\/08\/yuji-scaled.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"2560\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Gesch\u00e4tzte Lesezeit\" \/>\n\t<meta name=\"twitter:data1\" content=\"2\u00a0Minuten\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.h-its.org\\\/de\\\/event\\\/hits-simplaix-joint-colloquium-yuji-sugita\\\/\",\"url\":\"https:\\\/\\\/www.h-its.org\\\/de\\\/event\\\/hits-simplaix-joint-colloquium-yuji-sugita\\\/\",\"name\":\"HITS-SIMPLAIX Joint Colloquium Yuji Sugita - How Can Protein Droplets Be Dissolved? 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