How Human Cells Can Dissolve Damaging Protein Aggregates

Heidelberg researchers decode fundamental mechanism using in-vitro experiments Cellular repair systems can dissolve aggregated proteins and now Heidelberg researchers have successfully decoded the fundamental mechanism that is key to dissolving these protein aggregates in human cells. Their in-vitro experiments uncovered a multi-stage biochemical process in which protein molecules are dissolved from the aggregates. Researchers at…


International Summer Science School 2015 at HITS

Once again HITS welcomes two students in the framework of the International Summer Science School Heidelberg (ISH). The project allows young people from Heidelberg’s sister cities and partner organizations who are interested in natural sciences to get a practical insight into the laboratories of renowned research institutes here in Heidelberg. This year’s students that get…


Congratulations Xiaofeng Yu

We would like to congratulate Xiaofeng Yu who successfully defended his PhD thesis today! Congratulations! The whole MCM group wishes him all the best for his future.








HITS scientists building bioinformatics networks

HITS scientists Jonathan Fuller and Xiaofeng Yu have been involved in co-founding the Heidelberg Unseminars in Bioinformatics (HUB) along with colleagues from HITS and other research institutes and companies in Heidelberg (EMBL, DKFZ, Uni Heidelberg, Cellzome and more). HUB eschews some of the typical formats used to spread scientific ideas such as conferences and seminars,…


TRAPP on the Frontpage

An article by HITS researcher Dr. Daria Kokh (MCM) has made it onto the frontpage of the Journal of Chemical Information and Modeling. TRAPP (A Tool for Analysis of Transient Binding Pockets in Proteins) is a new automated software platform for tracking, analysis, and visualization of binding pocket variations along a protein motion trajectory or…


Rebecca Wade associate editor for scientific journal

Rebecca Wade, leader of the MCM group, has been appointed as an associate editor for the journal PLOS Computational Biology. PLOS Computational Biology aims at publishing outstanding primary research articles on all aspects of computational biology applied to different and integrated biological scales, from molecules and cells to patient populations and ecosystems. With this appointment,…


The Human Brain Project has begun

The world’s most ambitious neuroscience project is underway. Scientists from the 135 partner institutions of the Human Brain Project, co-funded by the EU with an estimated budget of €1.2 billion, are meeting in Switzerland for the official launch. One of the principle investigators in this international project is HITS researcher Rebecca Wade. With more than…


Exploring Drug-Target Interactions

HITS Scientists Participate in a New European Research Project In drug discovery it is often difficult to predict if a potential drug will be effective in humans. Recent studies have shown that the kinetics of the interaction between a drug and its target has a strong influence on the clinical success of a drug.  “Kinetics…


Publication in “Nature Structural & Molecular Biology”

HITS Researchers participate in a project that reveals the mechanism of molecular chaperones – Publication in Nature Structural & Molecular Biology Together with researchers from Heidelberg University and the German Cancer Research Center DKFZ, Rebecca Wade and Mykhaylo Berynskyy (MCM group) revealed the functional mechanism of molecular chaperones, repair systems for aggregated proteins. Protein aggregation…