BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//HITS - ECPv6.15.20//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-ORIGINAL-URL:https://www.h-its.org
X-WR-CALDESC:Events for HITS
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:Europe/Berlin
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20180325T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20181028T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20190331T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20191027T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20200329T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20201025T010000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=Europe/Berlin:20191216T110000
DTEND;TZID=Europe/Berlin:20191216T120000
DTSTAMP:20260424T015306
CREATED:20191125T123642Z
LAST-MODIFIED:20260126T100246Z
UID:41453-1576494000-1576497600@www.h-its.org
SUMMARY:Integrative Modeling of Allosteric Modulation in Pentameric Ligand-Gated Ion Channels
DESCRIPTION:By Erik Lindahl\, Stockholms universitet\, Department of Biochemistry and Biophysics\, Stockholm\, Sweden \nLigand-gated ion channels control the electrical excitation of nerve cells\, in particular in the post-synaptic membrane in response to chemical signals mediated by neurotransmitters. These receptors exhibit an amazing diversity in detailed structure and function – some human channels have 15-20 slightly genes\, and with five subunits this can theoretically lead to almost a million different oligomers. They are further characterised by adopting both closed\, open and desensitised states – and in addition to the neurotransmitters causing normal opening they are subject to secondary control – allosteric modulation – by a number of drugs such as alcohols\, benzodiazepines\, neurosteroids\, and anaesthetics that either potentiate or inhibit the agonist response. I will present our work on understanding the molecular mechanisms of these channels by using a broad range of experimental and theoretical methods\, and illustrate that while each method has many shortcomings their combination increasingly enable us to capture different timescales\, features\, interactions and not least dynamics of important membrane proteins. For ligand-gated ion channels in particular\, I will illustrate how this is enabling us to explain several key mechanisms\, including identifying the separate potentiating and inhibitory binding sites\, showing how we can reverse the allosteric modulation of specific channels\, to propose detailed functional models even from intermediate-resolution structural data – and not least start to understand the critical interplay of how lipids modulate membrane protein function. \n  \n  \nREGISTRATION: \nFor registration please contact Benedicta Frech: benedicta.frech@h-its.org \nIn case you are not able to attend in person\, you can watch the talk afterwards on the HITS YouTube channel: https://www.youtube.com/user/TheHITSters.\nThe colloquium will be live streamed\, please use the following link: https://hitsmediaweb.h-its.org/Mediasite/Play/304530a014b24e9d9154a06856cc888e1d
URL:https://www.h-its.org/event/colloquium-erik-lindahl/
CATEGORIES:Colloquia,Public Events
ATTACH;FMTTYPE=image/jpeg:https://www.h-its.org/wp-content/uploads/2019/11/Lindahl.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Berlin:20191118T110000
DTEND;TZID=Europe/Berlin:20191118T120000
DTSTAMP:20260424T015306
CREATED:20191010T082929Z
LAST-MODIFIED:20191114T095059Z
UID:40444-1574074800-1574078400@www.h-its.org
SUMMARY:Colloquium Keith A. Crandall: Computational Approaches for Characterizing Microbiome Diversity
DESCRIPTION:By Keith A. Crandall\, PhD\, Professor ob Biostatistics & Bioinformatics\, Director – Computational Biology Institute\, Milken Institute School of Public Health\, George Washington University\, Washington\, DC\, USA \n  \nMicrobiome characterization has become an integral component to the study of a wide variety of disease and health for a diversity of organisms. Through the collection of metagenomic sequence data from DNA and/or RNA samples isolated from host individuals\, effective microbiome characterization can identify pathogens\, link diversity to disease state\, characterize treatment effects\, and identify drug resistant variants. I present a computational platform\, PathoScope\, for metagenomic sequence analysis to characterize microbiome diversity and test hypotheses about diversity associates with disease and diversity dynamics over time. I then describe a second software package\, TeleScope\, that characterizes transposable elements in genomic data (a part of the microbiome component often ignored)\, maps those elements back to reference genomes\, and identifies active mobile elements and their potential phenotypic impact. I present results from both empirical studies and simulation studies characterizing the utility of our computational approaches with metagenomic data and compare our approach to other leading packages. I then demonstrate our computational tools with applications in endangered species conservation\, agriculture\, and a variety of aspects of human health. Specifically\, I will demonstrate the use of microbiome characterization related to black rhino health\, human health related to Konzo disease\, and human fecal transplant diversity over time. Finally\, I will demonstrate the characterization of human endogenous retroviral elements (HERVs) in relation to head and neck cancer and incorporate this information into risk assessment. \n  \nCurriculum vitae: \nKeith A. Crandall\, PhD is the Founding Director of the Computational Biology Institute and Professor in the Department of Biostatistics and Bioinformatics at George Washington University. Professor Crandall studies the computational biology\, population genetics\, and bioinformatics\, developing and testing methods for DNA sequence analysis. He applies such methods to the study of the evolution of both infectious diseases (especially microbiome diversity) and crustaceans (especially Decapod crustaceans). Professor Crandall has published over 300 peer reviewed publications\, as well as three books. He has been a Fulbright Visiting Scholar to Oxford University and an Allen Wilson Centre Sabbatical Fellow at the University of Auckland. Professor Crandall has received a number of awards for research and teaching\, including the American Naturalist Society Young Investigator Award\, an NSF CAREER Award\, a PhRMA Foundation Faculty Development Award in Bioinformatics\, Honors Professor of the Year award at Brigham Young University\, ISI Highly Cited Researcher\, and the Edward O. Wilson Naturalist Award. He is an elected Fellow in the American Association for the Advancement of Science (AAAS) and a Fellow of the Linnean Society of London. Professor Crandall earned his BA degree from Kalamazoo College in Biology and Mathematics\, an MA degree from Washington University in Statistics\, and a PhD from Washington University School of Medicine in Biology and Biomedical Sciences. He also served as a Peace Corps Volunteer in Puyo\, Ecuador. \n  \nREGISTRATION: \nFor registration please contact Benedicta Frech: benedicta.frech@h-its.org \nIn case you are not able to attend in person\, you can watch the talk afterwards on the HITS YouTube channel: https://www.youtube.com/user/TheHITSters.\nThe colloquium will be live streamed\, please use the following link: https://hitsmediaweb.h-its.org/Mediasite/Play/38f46c0cc6a04bf09aa74b955894fe531d\n\n 
URL:https://www.h-its.org/event/colloquium-keith-a-crandall/
LOCATION:Studio Villa Bosch\, Schloss-Wolfsbrunnenweg 33\, Heidelberg\, 69118\, Germany
CATEGORIES:Colloquia,Public Events
ATTACH;FMTTYPE=image/jpeg:https://www.h-its.org/wp-content/uploads/2019/10/Keith-Crandall.jpeg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Berlin:20191021T110000
DTEND;TZID=Europe/Berlin:20191021T120000
DTSTAMP:20260424T015306
CREATED:20190916T123748Z
LAST-MODIFIED:20190917T093257Z
UID:39910-1571655600-1571659200@www.h-its.org
SUMMARY:Colloquium Nicholas G. Reich: The Computational Science of Real-time Influenza Forecasting
DESCRIPTION:By Nicholas G. Reich\, Department of Biostatistics and Epidemiology\, University of Massachusetts\, School of Public Health and Health Sciences\, Amherst\, USA \nSeasonal influenza outbreaks cause substantial annual morbidity and mortality worldwide. Accurate forecasts of key features of influenza epidemics\, such as the timing and severity of the peak incidence in a given season\, can inform public health response to outbreaks. As part of ongoing efforts to incorporate real-time data and advanced computational methods into public health decision-making\, the United States Centers for Disease Control and Prevention (CDC) has organized real-time seasonal influenza forecasting challenges since 2013. This talk will summarize the recent collaborative efforts by the FluSight Network consortium to improve real-time forecast accuracy through multi-model ensemble forecasting. We will discuss the process of building and evaluating ensemble approaches\, each of which combines over 20 separate component model predictions into a single probabilistic forecast. During the Northern hemisphere winter influenza season\, the forecasts from the FluSight Network are publicly reported by the CDC as part of an official weekly communication to inform health practitioners about seasonal influenza trends. Past forecasts are available via an interactive data visualization at http://flusightnetwork.io. This talk will highlight the interdisciplinary challenges in designing\, implementing\, evaluating\, and communicating forecasts in a public health context.  \nCurriculum vitae:\nNicholas G Reich is an Associate Professor of Biostatistics at the University of Massachusetts – Amherst. His research group\, the Reich Lab (https://reichlab.io)\, focuses on developing statistical models for infectious disease dynamics. To forecast outbreaks of diverse infectious diseases (including dengue fever and influenza) and to assist with other outbreak response efforts\, his team has developed computational methods and user-friendly tools for analyzing real-time infectious disease surveillance data. He received a Young Faculty Director’s Award from the U.S. Defense Advanced Research Projects Agency (DARPA) and in 2015 earned first place for Outstanding Research Articles in Biosurveillance from the International Society of Disease Surveillance. Dr. Reich is the director of an Influenza Forecasting Center of Excellence\, funded by the U.S. Centers for Disease Control and Prevention (CDC). For the 2019/2020 academic year\, Dr. Reich is a visiting scholar at the LMU-Munich Department of Statistics\, supported by an Alexander von Humboldt Fellowship.  \nREGISTRATION: \n\nFor registration please contact Benedicta Frech: benedicta.frech@h-its.org \nIn case you are not able to attend in person\, you can watch the talk afterwards on the HITS YouTube channel: https://www.youtube.com/user/TheHITSters.\nThe colloquium will be live streamed\, please use the following link: https://hitsmediaweb.h-its.org/Mediasite/Play/a7cd0da6511c4d42b4460b003c537c981d
URL:https://www.h-its.org/event/colloquium-reich/
LOCATION:Studio Villa Bosch\, Schloss-Wolfsbrunnenweg 33\, Heidelberg\, 69118\, Germany
CATEGORIES:Colloquia,Public Events
ATTACH;FMTTYPE=image/jpeg:https://www.h-its.org/wp-content/uploads/2019/09/Nicholas_Reich.jpeg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Berlin:20191007T160000
DTEND;TZID=Europe/Berlin:20191007T170000
DTSTAMP:20260424T015306
CREATED:20190902T134100Z
LAST-MODIFIED:20190905T104540Z
UID:39315-1570464000-1570467600@www.h-its.org
SUMMARY:Vortrag Prof. Dr. Andreas von Bubnoff\, HITS Journalist in Residence 2019: Auf der Suche nach der Wahrheit - Wissenschaftsjournalismus in Zeiten von post-truth und reproducibility crisis
DESCRIPTION:Die Wahrheit\, so scheint es\, hat es schwer heutzutage: Oxford Dictionaries erklärte “post-truth” zum internationalen Wort des Jahres 2016; Fake News verbreiten sich oft schneller\, als sie entlarvt werden können; und der Relotius-Skandal offenbarte Schwachstellen beim Faktencheck im deutschen Journalismus. Auch in der Wissenschaft gibt es Probleme: Wissenschaftliche Studien\, etwa zur Ernährung\, widersprechen sich allzu oft; zahlreiche Studien sind nicht reproduzierbar; und schwach belegte oder sogar widerlegte Theorien halten sich bisweilen überraschend lange.​ \nWie ernst sind diese Probleme wirklich\, wie konnte es dazu kommen\, und wie können wir das Vertrauen der Bevölkerung in die Wissenschaft und den Journalismus erhalten bzw. wiederherstellen? HITS Journalist in Residence Prof. Dr. Andreas von Bubnoff\, der lange Jahre als Wissenschaftsjournalist in den USA tätig war\, wird versuchen\, diese Fragen zu beantworten. \nCV: http://andreasvonbubnoff.squarespace.com/ \n  \nREGISTRIERUNG: \n\nFalls Sie an der Veranstaltung teilnehmen möchten\, wenden Sie sich bitte an Benedicta Frech (Benedicta.frech@hits.org).\nFür alle\, die nicht persönlich zur Veranstaltung kommen können: Das Kolloquium wird live gestreamt. Bitte benutzen Sie den folgenden Link: https://hitsmediaweb.h-its.org/Mediasite/Play/fa84ced26eec44369988b7a1b68a92001d\nDas Video des Vortrags wird außerdem im Anschluss auch auf dem HITS YouTube Kanal verfügbar sein: https://www.youtube.com/user/TheHITSters.
URL:https://www.h-its.org/event/vortrag-prof-dr-andreas-von-bubnoff/
CATEGORIES:Colloquia,Public Events
ATTACH;FMTTYPE=image/jpeg:https://www.h-its.org/wp-content/uploads/2019/08/Bubnoff.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Berlin:20190909T110000
DTEND;TZID=Europe/Berlin:20190909T120000
DTSTAMP:20260424T015306
CREATED:20190715T122756Z
LAST-MODIFIED:20190827T150307Z
UID:38362-1568026800-1568030400@www.h-its.org
SUMMARY:Colloquium Richard A. Bonneau: Large Scale Machine Learning Methods for Predicting Protein Functions from integration of Sequence\, Structure and Networks
DESCRIPTION:By Prof. Dr. Richard A. Bonneau\, Professor of Biology and Computer Science; Director\, NYU Center for Data Science\, New York\, USA \nVladimir Gligorijevic\, P Douglas Renfrew and Richard Bonneau. \nDue to limitations of existing experimental methods for determining protein functions and the high cost of experiments\, the vast majority of proteins across many organisms remain unannotated.  Developing ML methods for combining large-scale genome-wide heterogeneous data to extract useful protein feature representations for function prediction thus remains a key problem in biology.   This problem also serves to illustrate many general aspects of multiple applications of machine learning to biological sequences. We will review a few of our recent deep learning-based methods for predicting function from various data types\, including protein sequences\, structures and protein-protein interaction networks. We will first present our recent integrative method\, deepNF (deep network fusion) that integrates different protein-protein interaction networks using multi-modal network auto-encoders to construct a shared protein feature representation indicative of protein function. In the second part of the talk\, we will focus on methods for predicting function from combining protein sequence and structure. This discussion will center on a method based on graph convolutional networks (GCNs) which extracts features from protein contact maps and sequences while learning to predict function. We will discuss the performance of GCN in predicting functions of experimentally determined structures from PDB and how we are planning on applying this method on Rosetta-predicted structures.  Our hope is to predict protein function in a manner that allows us to map the predicted function back to residues\, locations on structures\, and network neighborhoods in manner that facilitates experimental followup. \nCurriculum vitae: \nDr. Bonneau is Group Leader for Systems Biology at the newly founded Flatiron Institute in New York City and also Director of the New York University Center for Data Science.  His group works on inferring and modeling both biological and social networks (at the Simons foundation and the SMaPP lab at NYU respectively)\, developing new methods to learn very large networks from large collections of genomics data.   His group actively participates in applying these methods to ongoing systems biology consortia efforts that span bacteria\, model systems\, bacteria\, the immune system and crop plants. His group also develops methods for the prediction and design of bio molecular polymers (and polymers that mimic biological structure).  To carry out this work his group develops Rosetta as a core member of the RosettaCommons; Dr. Bonneau is a founding member of the Rosetta commons and a member of the RosettaCommons executive board. Dr. Bonneau is committed to doing all he can to leverage his position as Director of the Center for Data Science to help increase diversity in the many computational fields that comprise what we today refer to as the field of data science. \nREGISTRATION: \n\nFor registration please contact Benedicta Frech: benedicta.frech@h-its.org \nIn case you are not able to attend in person\, you can watch the talk afterwards on the HITS YouTube channel: https://www.youtube.com/user/TheHITSters.\nThe colloquium will be live streamed\, please use the following link: https://hitsmediaweb.h-its.org/Mediasite/Play/0d38e9bc22344589b572c45a711af3671d
URL:https://www.h-its.org/event/colloquium-richard-bonneau/
LOCATION:Studio Villa Bosch\, Schloss-Wolfsbrunnenweg 33\, Heidelberg\, 69118\, Germany
CATEGORIES:Colloquia,Public Events
ATTACH;FMTTYPE=image/jpeg:https://www.h-its.org/wp-content/uploads/2019/07/Rich-Bonneau.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Berlin:20190715T110000
DTEND;TZID=Europe/Berlin:20190715T120000
DTSTAMP:20260424T015306
CREATED:20190709T083656Z
LAST-MODIFIED:20190709T122906Z
UID:38274-1563188400-1563192000@www.h-its.org
SUMMARY:Colloquium Peter Hunter: Computational Physiology and the Physiome Project
DESCRIPTION:By Prof. Dr. Peter Hunter\, Auckland Bioengineering Institute\, University of Auckland\, New Zealand \nComputational physiological models deal with multiple physical processes (coupled tissue mechanics\, electrical activity\, fluid flow\, etc) at multiple spatial and temporal scales. In many cases the goal is to understand integrative biological function in terms of underlying tissue structure and molecular mechanisms. These models are intended both to help understand physiological function and to provide a basis for diagnosing and treating pathologies in a clinical setting. The Physiome Project is developing model and data encoding standards\, web accessible databases and open source software for multiscale modelling (e.g. www.cellml.org). A new journal called Physiome will soon be launched to publish reproducible and reusable models. The talk will discuss the current state of the Physiome Project\, including a summary of a multi-physics mathematical framework based on port-Hamiltonians for modelling physiology\, and a project to map the pathways of the autonomic nervous system (commonfund.nih.gov/sparc). \nCurriculum vitae: \nProfessor Peter Hunter is Director of the Auckland Bioengineering Institute (ABI) at the University of Auckland\, and founding Director of the Medical Technologies Centre of Research Excellence (MedTech CoRE). His research interests are in modeling human physiology using an anatomical and biophysically-based multiscale approach that links molecular processes to tissue level phenotypes. He was awarded the Rutherford Medal and a KEA World Class NZ award in 2009 and appointed to the NZ Order of Merit in 2010. He is an elected Fellow of the Royal Society (London and NZ)\, President of the World Council of Biomechanics\, 2nd Vice-President of the International Union of Physiological Sciences (IUPS)\, and past-Chair of the International Academy of Medical and Biological Engineering. \nRegistration is closed. \nThe colloquium will be live streamed\, please use the following link: https://hitsmediaweb.h-its.org/Mediasite/Play/22f74231fb8f494ab7b719c52b17d5a01d
URL:https://www.h-its.org/event/colloquium-peter-hunter/
LOCATION:Studio Villa Bosch\, Schloss-Wolfsbrunnenweg 33\, Heidelberg\, 69118\, Germany
CATEGORIES:Colloquia,Public Events
ATTACH;FMTTYPE=image/jpeg:https://www.h-its.org/wp-content/uploads/2019/07/Hunter.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Berlin:20190712T160000
DTEND;TZID=Europe/Berlin:20190712T170000
DTSTAMP:20260424T015306
CREATED:20190517T134433Z
LAST-MODIFIED:20190627T123325Z
UID:35866-1562947200-1562950800@www.h-its.org
SUMMARY:Colloquium Rainer Malaka: Empowering People with Digital Media: Playful and Natural Human Computer Interaction
DESCRIPTION:By Prof. Dr. Rainer Malaka\, Technology Center Informatics and Information Technology (TZI)\, University of Bremen\nDigital Media are omnipresent and ubiquitous phenomena. The digital revolution has already transformed our lives and societies. This trend will continue and include more devices in our surrounding such as cars and household robots. In this new digital society\, Human Computer Interaction (HCI) will shape the way we think\, communicate\, and work. We co-exist in a digital society with a global infrastructure of information technology. The talk will look at perspectives of HCI that supports humans in their abilities and motivates them in solving their everyday tasks. Playful elements and computer games seem to be promising tools to shape new forms of interaction that turn tedious work into playful activities. We will look at some techniques from entertainment computing and discuss their potential for HCI and serious applications.\nThe talk will give a number of examples of systems that show how natural and playful interaction can be used for empowering people with digital media. \nCurriculum vitae:\nRainer Malaka is Professor for Digital Media at the University of Bremen since 2006. The focus of Dr. Malaka’s work is Digital Media\, Interaction\, and Entertainment Computing. At the University of Bremen\, he directs a Graduate College “Empowering Digital Media” funded by the Klaus Tschira Foundation. He is also director of the TZI\, the center for computing technologies at the University of Bremen. Before joining the University of Bremen\, he led a research group at the European Media Lab in Heidelberg. He did his PhD at the University of Karlsruhe on modeling brain structures using neural networks. He is also steering board member of the Interdisciplinary College for multiple years\, a multidisciplinary international spring school on cognitive science\, neurosciences and AI.\nRainer Malaka is the German representative in and chair of IFIP’s technical committee TC14 for Entertainment Computing. \nREGISTRATION: \n\nFor registration please contact Benedicta Frech: benedicta.frech@h-its.org \nIn case you are not able to attend in person\, you can watch the talk afterwards on the HITS YouTube channel: https://www.youtube.com/user/TheHITSters.
URL:https://www.h-its.org/event/colloquium-rainer-malaka/
LOCATION:Studio Villa Bosch\, Schloss-Wolfsbrunnenweg 33\, Heidelberg\, 69118\, Germany
CATEGORIES:Colloquia,Public Events
ATTACH;FMTTYPE=image/jpeg:https://www.h-its.org/wp-content/uploads/2019/05/Rainer-Malaka2.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Berlin:20190502T090000
DTEND;TZID=Europe/Berlin:20190502T130000
DTSTAMP:20260424T015306
CREATED:20190424T080920Z
LAST-MODIFIED:20230111T110821Z
UID:35269-1556787600-1556802000@www.h-its.org
SUMMARY:International Symposium Computational Astrophysics
DESCRIPTION:From 2-3 May 2019 the International Symposium Computational Astrophysics takes place in the Studio Villa Bosch Heidelberg. \nRegistration:\nchristina.blach@h-its.org \nParking:\n„Unter der Boschwiese“ (free of charge)
URL:https://www.h-its.org/event/international-symposium-computational-astrophysics/
LOCATION:Studio Villa Bosch\, Schloss-Wolfsbrunnenweg 33\, Heidelberg\, 69118\, Germany
CATEGORIES:Colloquia
ATTACH;FMTTYPE=image/jpeg:https://www.h-its.org/wp-content/uploads/2019/04/Vorder-und-Rückseite-des-Gebäudes_Garten-1.jpg
END:VEVENT
END:VCALENDAR