An interdisciplinary team of researchers from Heidelberg is working together to develop mathematical modeling to help decipher tumor development in hereditary colorectal cancer. The research project includes mathematicians and tumor biologists from the Heidelberg Institute for Theoretical Studies (HITS), Heidelberg University, Heidelberg University Hospital and the German Cancer Research Center (DKFZ). The project is funded by the Klaus Tschira Foundation. The aim of the collaborative project is to understand tumor initiation, evolution, and immunology by means of mathematical modeling and thereby find approaches to potentially prevent hereditary cancer in the future.
Colorectal cancer is one of the most common cancers worldwide and has become increasingly prevalent in younger generations in recent years. A substantial proportion of colorectal tumors in young patients are hereditary, with Lynch syndrome being the most common hereditary colorectal cancer syndrome. Lynch syndrome carriers have an increased risk of colorectal cancer, as well as malignancies in other organs. Therefore, the development of effective preventive measures is a highly relevant topic in modern medicine.
Cancer development is a complex process that can be influenced by numerous factors. In addition, investigations are usually performed on tumors that have already developed, but these represent only a snapshot of the overall developmental process. So far, only a few conclusions can be drawn about the individual steps in this development process and their sequence.
The research team will now combine mathematical modeling and medical data to track the cancer formation processes before they are visible in medical examinations. Therefore, a decisive factor in this research work is the close interdisciplinary exchange between mathematics and medicine, for which Heidelberg offers the perfect research environment. By developing a common language between medicine and mathematics, medical hypotheses can be translated into mathematical equations. This translation work will be the core of the upcoming interdisciplinary collaboration.
The Heidelberg project entitled “Mathematics in Oncology” is a pilot initiative to strengthen interdisciplinary translational research. Through the three-year funding, the Klaus Tschira Foundation is supporting an interdisciplinary project that enables new synergies between mathematics and medicine and strengthens the innovative research profile of Heidelberg as a center of science.
HITS, the Heidelberg Institute for Theoretical Studies, was established in 2010 by physicist and SAP co-founder Klaus Tschira (1940-2015) and the Klaus Tschira Foundation as a private, non-profit research institute. HITS conducts basic research in the natural, mathematical, and computer sciences. Major research directions include complex simulations across scales, making sense of data, and enabling science via computational research. Application areas range from molecular biology to astrophysics. An essential characteristic of the Institute is interdisciplinarity, implemented in numerous cross-group and cross-disciplinary projects. The base funding of HITS is provided by the Klaus Tschira Foundation.