MBM Group
Molecular Biomechanics

Projects

Current Projects

Diffusion models for protein design

6. May 2024

Generative deep learning has transformed protein design, enabling the creation of new protein structures, interactions, and functions with high precision, by …

Read more

Mechanoradicals and DOPA in Collagen Tissue

13. December 2021

– A role for dihydroxyphenylalanine (DOPA) as a marker of mechanical stress and radical scavenger in collagen – Collagen is responsible for the …

Read more

Emulation in simulation

1. June 2021

“Emulation in simulation” combines HITS’ expertise in computational statistics and numerical simulation to develop a new generation of surrogate model tools. …

Read more

Intrinsically disordered Proteins

12. March 2021

Intrinsically disordered proteins (IDPs) are a new class of proteins that lack secondary and tertiary structures and instead explore a broad …

Read more

Simulations of Collagen Failure and Mechanoradicals

24. February 2021

It has been known for many decades that synthetic polymers subjected to mechanical stress generate mechanoradicals by rupture of chemical bonds. …

Read more

Mechanokinases

24. February 2021

Kinases are abundantly present in all cells and involved in the regulation of many important processes, such as cell survival, growth, …

Read more

Force-triggered blood coagulation

30. January 2021

Von Willebrand factor (VWF) is a giant multidomain extracellular blood protein in charge of a key adhesive process during hemostasis: the …

Read more

Previous Projects

Does the quality of writing influence the impact of scientific papers?

1. June 2021

The importance and quality of a new discovery presented in a scientific article is often evaluated by the number of its …

Read more

Mechanical properties of silk

18. December 2014

Silk is one of the many biomaterials with mechanical properties not yet reached by synthetic counterparts. Silk fibers have an outstanding …

Read more

Mechanical properties of Nacre

2. December 2014

Nacre, also known as mother-of-pearl, is a biocomposite located at the inner layer of seashells, with exceptional mechanical properties such as …

Read more

Structure-based Drug design

14. November 2014

Structure-based design methods have proven effective in every aspect of drug design – from lead discovery, development, through guiding clinical trials. …

Read more

Force-driven allostery in proteins

11. November 2014

Allostery in proteins plays a significant role such as cell signalling or gene and enzyme regulations. Allostery is characterized by a …

Read more

Mechano(bio)chemistry

30. October 2014

Chemical and enzymatic reactions can be guided by mechanical stress. While single molecule force spectroscopy is an emerging technique to study …

Read more

Force distribution analysis (FDA)

30. October 2014

Force distribution analysis (FDA) is a method to detect and follow force and stress propagation in proteins, reminiscent of Finite Element …

Read more

Switch to the German homepage or stay on this page