A step-forward in understanding von Willebrand factor
It’s a pleasure to announce advancements in our understanding of von Willebrand factor. The article describes a new mechanism of how von Willebrand factor is auto-inhibited for platelet binding and how this inhibition is released by mechanical force. Our computations were supported by experiments of our collaborators in Mannheim, Linz, and Hamburg.
For more information the published work is accessible here.
About HITS
HITS, the Heidelberg Institute for Theoretical Studies, was established in 2010 by physicist and SAP co-founder Klaus Tschira (1940-2015) and the Klaus Tschira Foundation as a private, non-profit research institute. HITS conducts basic research in the natural, mathematical, and computer sciences. Major research directions include complex simulations across scales, making sense of data, and enabling science via computational research. Application areas range from molecular biology to astrophysics. An essential characteristic of the Institute is interdisciplinarity, implemented in numerous cross-group and cross-disciplinary projects. The base funding of HITS is provided by the Klaus Tschira Foundation.
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