MBM Group
Molecular Biomechanics

Projects

Current Projects

Emulation in simulation

1. June 2021

“Emulation in simulation” combines HITS’ expertise in computational statistics and numerical simulation to develop a new generation of surrogate model tools. …

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Intrinsically disordered Proteins

12. March 2021

Intrinsically disordered proteins (IDPs) are a new class of proteins that lack secondary and tertiary structures and instead explore a broad …

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Mechanoradicals in Collagen

24. February 2021

It has been known for many decades that synthetic polymers subjected to mechanical stress generate mechanoradicals by rupture of chemical bonds. …

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Mechanokinases

24. February 2021

Kinases are abundantly present in all cells and involved in the regulation of many important processes, such as cell survival, growth, …

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Force-triggered blood coagulation

30. January 2021

Von Willebrand factor (VWF) is a giant multidomain extracellular blood protein in charge of a key adhesive process during hemostasis: the …

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Previous Projects

Does the quality of writing influence the impact of scientific papers?

1. June 2021

The importance and quality of a new discovery presented in a scientific article is often evaluated by the number of its …

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Mechanical properties of silk

18. December 2014

Silk is one of the many biomaterials with mechanical properties not yet reached by synthetic counterparts. Silk fibers have an outstanding …

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Mechanical properties of Nacre

2. December 2014

Nacre, also known as mother-of-pearl, is a biocomposite located at the inner layer of seashells, with exceptional mechanical properties such as …

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Structure-based Drug design

14. November 2014

Structure-based design methods have proven effective in every aspect of drug design – from lead discovery, development, through guiding clinical trials. …

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Force-driven allostery in proteins

11. November 2014

Allostery in proteins plays a significant role such as cell signalling or gene and enzyme regulations. Allostery is characterized by a …

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Mechano(bio)chemistry

30. October 2014

Chemical and enzymatic reactions can be guided by mechanical stress. While single molecule force spectroscopy is an emerging technique to study …

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Force distribution analysis (FDA)

30. October 2014

Force distribution analysis (FDA) is a method to detect and follow force and stress propagation in proteins, reminiscent of Finite Element …

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