Accessible and shareable health information is crucial for good healthcare. Scientists of the Scientific Databases and Visualization group (SDBV) at HITS are involved in the project “EU-Standards for Personalised Medicine” (EU-STANDS4PM), which encourages collaborative research to accelerate health science. Funded by the EU program H2020, the three-year project will establish a pan-European expert forum to assess and evaluate national standardization strategies for health data integration and data-driven computer modeling approaches.
Tumor invasion and metastasis are major problems in the therapy of cancer patients. A team of researchers at the Heidelberg Institute of Theoretical Studies (HITS), the LMU Munich (both Germany) and the CNIO Madrid, Spain, has now elucidated the activation conditions for a key enzyme in this process – a step forward in the development of new therapeutic strategies.
HITS is partner of the international research consortium “MESI-STRAT” that explores the interplay of breast cancer metabolism and oncogenic signaling by systems medicine. The consortium was awarded by the European Union €6 million for five years. The main goal of the five-years project is to develop new models for knowledge-based stratification of patients into subgroups to guide targeted interventions. The Scientific Databases and Visualization (SDBV) group at HITS takes care of the model and data management platform.
Since it opened in April 2018, the ESO Supernova Planetarium & Visitor Centre has shared the wonders of the Universe with more than 55 000 visitors and captured the attention of audiences from around the globe. Now, the ESO Supernova’s extensive library of high-resolution images, stunning videos, educational texts and planetarium resources, as well as a digital version of its state-of-the-art astronomical exhibition, have been made freely available online.
A team of international researchers just published a new study on Hemiptera, using a vast amount molecular data to investigate their evolutionary history of more than 350 million years. An important part of the study was the reconstruction of the phylogenetic trees with a tool developed in the Scientific Computing group at HITS, Heidelberg. The reconstruction was performed on the supercomputer SuperMUC in Garching near Munich.
German Scientists investigate the structure of the von Willebrand factor (VWF), a key protein involved in blood clotting. HITS researchers from the Molecular Biomechanics group simulated the dynamics of the platelet integrin-binding VWF C4 domain to better understand disease mutations of this protein. The project was supported by the Deutsche Forschungsgemeinschaft (DFG).
2019 marks the beginning of one of the biggest projects for data management in astronomy. The „European Science Cluster for Astronomy & Particle physics ESFRI research infrastructures” (short: ESCAPE) is a consortium of more than 30 European partners that is now developing different strategies to facilitate the management of data-driven research. The project aims, among other things, to make the European science cloud reality and to create infrastructures and methods to deal with the increasing amount of data in astronomy.
Parasitic wasps existed as early as several million years ago. Within a project coordinated by Karlsruhe Institute of Technology (KIT), researchers of various disciplines for the first time definitively discovered fossil parasites inside their hosts. The scientists studied fly pupae from old collections using ultrafast X-ray imaging. They found 55 cases of parasitation and described four extinct wasp species that were unknown until now. The project was managed by the KIT. Researchers from HITS and Heidelberg University developed the algorithms and software for the digital reconstruction. Their findings are reported in Nature Communications.
Elementary cytoskeleton protein is different in parasites and represents a starting point for a possible new therapy against malaria infections. Researchers from the Heidelberg University Hospital, the Centre for Molecular Biology at the University of Heidelberg (ZMBH), and the Heidelberg Institute for Theoretical Studies (HITS) have published these findings in the journal “PLOS Biology”.
HITS researchers developed tauRAMD, a tool to predict drug-target residence times from short simulations. The method is illustrated on the cover page of July 2018 issue of the Journal of Chemical Theory and Computation, software is freely available.