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Mechanosensing ability of Focal Adhesion Kinase
Mechanosensing plays a decisive role at focal adhesions (Fas), sites at which external forces are integrated into cellular signaling pathways, thereby …
Composite Materials
Polymeric materials show outstanding mechanical properties and have attracted a great deal of scientific interest. By means of all-atom molecular dynamics, …
Focal Adhesion Kinase is a mechanosensor!
MD simulations of a FAK fragment containing the catalytic and FERM domains in different protein system are carried out to compare …
Proteins under shear flow
Shear flow, as it occurs for example in blood vessel, is an alternative way of subjecting proteins to forces for signalling …
Extremely elastic proteins
The ultimate properties of proteins with respect to their ability to be force-reactive, are coarsely described by their capacity to withstand …
Interaction between intrinsically disordered proteins and structured partners
On the line of maturing new understanding of the factors regulating the correct dynamics of intrinsically disordered proteins in solution, one …
Conformational dynamics of intrinsically disordered proteins
Intrinsically disordered proteins (IDPs) lack, by definition, of a well-defined three-dimensional structure and therefore explore a much larger conformational ensemble with …
How graphene sheets respond to force
Bogdan and Frauke have published two back-to-back articles (one together with the former member of the MBM group Dr. Ilona Baldus) …
Die Kraft, die im Molekül steckt
This content is only available in German. Dr. Frauke Gräter, Leiterin der Forschungsgruppe „Molecular Biomechanics“ am Heidelberger Institut für …
What Determines the Stability of Proteins?
With mathematical methods and computer simulations, Humboldt Fellow Richard Henchman (University of Manchester) is exploring the factors of protein stability – Research …
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