FAK allosteric network helps interpreting FRET measurements!
Jing’s allosteric network of focal adhesion kinase (FAK) when binding PIP2 helped to interpret recent FRET results in FAK activation …
Welcome Katra!
Dr. Katra Kolsek joins us as a postdoc to work on disulfides in the von Willebrand factor. Welcome!
Welcome Ana!
We are happy that Ana Herrera Rodriguez joins us as a PhD student to work on silk assembly under flow. Welcome!
Mechanosensing ability of Focal Adhesion Kinase
Mechanosensing plays a decisive role at focal adhesions (Fas), sites at which external forces are integrated into cellular signaling pathways, thereby …
Composite Materials
Polymeric materials show outstanding mechanical properties and have attracted a great deal of scientific interest. By means of all-atom molecular dynamics, …
Focal Adhesion Kinase is a mechanosensor!
MD simulations of a FAK fragment containing the catalytic and FERM domains in different protein system are carried out to compare …
Small change for a big improvement – halogen bonds and drug discovery
Diese Informationen sind leider nur in englischer Sprache verfügbar. Halogen chemistry has been exploited by medicinal chemists for nearly 70 years. …
Proteins under shear flow
Shear flow, as it occurs for example in blood vessel, is an alternative way of subjecting proteins to forces for signalling …
Extremely elastic proteins
The ultimate properties of proteins with respect to their ability to be force-reactive, are coarsely described by their capacity to withstand …
Interaction between intrinsically disordered proteins and structured partners
On the line of maturing new understanding of the factors regulating the correct dynamics of intrinsically disordered proteins in solution, one …